Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder

Deniz Uluhan Yıldırım; Cana Aksoy Poyraz; Burç Çağrı Poyraz; Armağan Özdemir; Alaattin Duran

doi:10.5455/jmood.20141101050757

2024, Vol: 14, Issue: 1

14 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

COPYRIGHT FORM
_Title_Page_Obligatory_(v2r)_

« Previous Article

Original Research

Online Publishing Date:
30 / 03 / 2015

PBS. 2015; 5(1): 16-22

doi: 10.5455/jmood.20141101050757

Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burç Çağrı Poyraz, Armağan Özdemir, Alaattin Duran.

Abstract
Objective: Neurocognitive impairments in bipolar patients as a possible endophenotype is a growing field of research. Impairments in executive functions and memory have been reported in relatives of patients with bipolar disorder, suggesting that they could be potential endophenotypes for genetic studies. In this study, neuropsychological performance in unaffected siblings of patients diagnosed as bipolar I disorder is compared to that of matched healthy controls.
Method: We evaluated 35 unaffected siblings of probands with bipolar I disorder and 35 healthy controls using tests of verbal fluency, attention, executive functions and memory. Rey Auditory Verbal Learning Test (RAVLT), Wechsler Memory Scale-Revised (WMS-R) visual memory test, Stroop Colour-Word Interference test (SCWIT), Trail Making Test-A and B, Wechsler Adult Intelligence Scale-Revised Digit Span test, categoric verbal fluency test (Isaac SET Test) , and clock drawing tests were performed.
Results: Unaffected siblings of patients with bipolar disorder performed poorly on the RAVLT, SCWIT, forward Digit Span Test, TMT-A and B, visual recall test. Using stepwise logictic regression TMT-B alone could highly differentiate siblings from controls.
Conclusion: We found significant impairment of set shifting task measured with TMT-B in siblings of patients with BD. Our study suggests that set shifting/cognitive flexibility could be a potential cognitive endophenotype for bipolar disorder.

Key words: bipolar disorder, endophenotype, cognitive functions

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Deniz Uluhan Yıldırım Articles by Cana Aksoy Poyraz Articles by Burç Çağrı Poyraz Articles by Armağan Özdemir Articles by Alaattin Duran
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. PBS. 2015; 5(1): 16-22. doi:10.5455/jmood.20141101050757

Web Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. https://www.pbsciences.org/?mno=161770 [Access: April 09, 2024]. doi:10.5455/jmood.20141101050757

AMA (American Medical Association) Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. PBS. 2015; 5(1): 16-22. doi:10.5455/jmood.20141101050757

Vancouver/ICMJE Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. PBS. (2015), [cited April 09, 2024]; 5(1): 16-22. doi:10.5455/jmood.20141101050757

Harvard Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran (2015) Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. PBS, 5 (1), 16-22. doi:10.5455/jmood.20141101050757

Turabian Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. 2015. Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. Psychiatry and Behavioral Sciences, 5 (1), 16-22. doi:10.5455/jmood.20141101050757

Chicago Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran. "Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder." Psychiatry and Behavioral Sciences 5 (2015), 16-22. doi:10.5455/jmood.20141101050757

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Deniz Uluhan Yıldırım, Cana Aksoy Poyraz, Burc Cağrı Poyraz, Armağan Ozdemir, Alaattin Duran (2015) Impairment of executive functions and memory in unaffected siblings of patients with bipolar disorder. Psychiatry and Behavioral Sciences, 5 (1), 16-22. doi:10.5455/jmood.20141101050757

Author Login Reviewer Login

About Psychiatry and Behavioral Sciences

Contact Information

How to cite this article