The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade

Olcay Senay; Yasin Hasan Balcioglu; Mehmet Cem Ilnem

doi:10.5455/PBS.20180628062738

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Case Report

PBS. 2018; 8(3):

doi: 10.5455/PBS.20180628062738

The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade

Olcay Senay, Yasin Hasan Balcioglu, Mehmet Cem Ilnem.

Abstract
Tuberous sclerosis (TSc) is an autosomal dominant multisystemic disorder. Mutant TSC1 and TSC2 are the responsible genes for the disorder that leading to a hyperactivation of the mammalian target of rapamycin (mTOR), a signaling cascade involved in cell growth, proliferation, protein synthesis, and metabolism. Everolimus and sirolimus, the mTOR inhibitors, are recently offered to restore pathologically up-regulated mTOR pathway in TSc. However, the neuropsychiatric side effects of these drugs are yet to be studied. Here we reported a 22-year-old male patient, with diagnoses of tuberous sclerosis, epilepsy, learning disability, and organic personality disorder without any psychotic manifestations, who was admitted to our outpatient clinic because of disorganized behavior, hallucinations, and delusions with a recent history of hostility and aggression. The aforementioned psychotic manifestations initiated soon after he had undergone on a placebo-controlled double-blind study of everolimus 6 mg/daily for TSc for last four months. Clinical examination, laboratory screening, and magnetic resonance imaging (MRI) of the brain have not revealed any other organic causes of psychosis. His symptoms resolved over the next ten or so days with moderate doses of antipsychotics. The current case is presented in order to discuss possible underlying neuronal signaling mechanisms those may lead psychosis following a short-term mTOR inhibition treatment. Although it would be difficult to allege the direct involvement of short-term everolimus exposure in the development of psychotic symptoms, impaired protein synthesis related to the mTOR inhibition leads to impaired neuronal network and plasticity, and may predispose to the development of psychotic symptoms, consequently.

Key words: Everolimus, mTOR, neuromodulation, neuronal plasticity, psychosis

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Pubmed Style

Senay O, Balcioglu YH, Ilnem MC. The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. PBS. 2018; 8(3): -. doi:10.5455/PBS.20180628062738

Web Style

Senay O, Balcioglu YH, Ilnem MC. The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. https://www.pbsciences.org/?mno=302642216 [Access: April 09, 2024]. doi:10.5455/PBS.20180628062738

AMA (American Medical Association) Style

Senay O, Balcioglu YH, Ilnem MC. The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. PBS. 2018; 8(3): -. doi:10.5455/PBS.20180628062738

Vancouver/ICMJE Style

Senay O, Balcioglu YH, Ilnem MC. The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. PBS. (2018), [cited April 09, 2024]; 8(3): -. doi:10.5455/PBS.20180628062738

Harvard Style

Senay, O., Balcioglu, . Y. H. & Ilnem, . M. C. (2018) The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. PBS, 8 (3), -. doi:10.5455/PBS.20180628062738

Turabian Style

Senay, Olcay, Yasin Hasan Balcioglu, and Mehmet Cem Ilnem. 2018. The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade. Psychiatry and Behavioral Sciences, 8 (3), -. doi:10.5455/PBS.20180628062738

Chicago Style

Senay, Olcay, Yasin Hasan Balcioglu, and Mehmet Cem Ilnem. "The Occurrence of Psychotic Manifestation Following the Initiation of Everolimus in a Patient with Tuberous Sclerosis: A Possible Involvement of Dysregulated mTOR Cascade." Psychiatry and Behavioral Sciences 8 (2018), -. doi:10.5455/PBS.20180628062738

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