E-ISSN 2636-834X
 

Original Research 
PBS. 2011; 1(1): 14-18


Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders

Murat Can, Berrak Güven, Levent Atik, Numan Konuk.

Abstract
AIM: Lipid peroxidation and antioxidant status are becoming attractive areas of research in mood disorders. To add a new insight to the question, changes in the serum lipid peroxidation products (MDA) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), were measured in patients with bipolar disorder and unipolar depression. This study was undertaken to assess oxidative stress and antioxidant status in patients with mood disorders.
Method: The study was conducted in 71 mood disorder patients (39 bipolar disorder and 32 unipolar depression) and compared to healthy controls (n=30). Levels of plasma MDA and activities of antioxidant enzymes SOD and GPX were measured. MDA was determined as the measure of thiobarbituric acid reactive substances. GPX activity was measured by the method of Paglia and Valentine. SOD activity was determined according to the method of Sun and colleagues. These parameters were measured in 71 patients and compared to controls.
Results: Serum SOD and GPX activities was strongly decreased in bipolar and depressed patients when compared to control group (p <0.05), but there was no difference between bipolar and depressed patients. Conversly, serum MDA concentration was siginificantly increased in bipolar and depressed patients when compared to control group (p<0.05), but there was no difference between bipolar and depressed patients.
Conclusions: Decreased activities of two antioxidant defense enzymes in the present study indicate an increased oxidative stress in mood disorder. Our results suggesting that the generation of reactive oxygen species associated with the oxidative stress may induce lipid oxidation and consequently decreasing antioxidant defence in mood disorders.

Key words: Mood disorders, bipolar disorder, unipolar depression, oxidative stress, lipid peroxidation


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Murat Can
Articles by Berrak Güven
Articles by Levent Atik
Articles by Numan Konuk
on Google
on Google Scholar

How to Cite this Article
Pubmed Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. PBS. 2011; 1(1): 14-18.


Web Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. http://www.pbsciences.org/?mno=7524 [Access: March 30, 2021].


AMA (American Medical Association) Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. PBS. 2011; 1(1): 14-18.



Vancouver/ICMJE Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. PBS. (2011), [cited March 30, 2021]; 1(1): 14-18.



Harvard Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk (2011) Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. PBS, 1 (1), 14-18.



Turabian Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. 2011. Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. Psychiatry and Behavioral Sciences, 1 (1), 14-18.



Chicago Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. "Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders." Psychiatry and Behavioral Sciences 1 (2011), 14-18.



MLA (The Modern Language Association) Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk. "Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders." Psychiatry and Behavioral Sciences 1.1 (2011), 14-18. Print.



APA (American Psychological Association) Style

Murat Can, Berrak Guven, Levent Atik, Numan Konuk (2011) Lipid peroxidation and serum antioxidant enzymes activity in patients with bipolar and major depressive disorders. Psychiatry and Behavioral Sciences, 1 (1), 14-18.