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Case Report 


CADASIL syndrome presenting with bipolar disorder

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıçaslan.

Cited by (1)

Abstract
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a small vessel disease, is characterized with subcortical infarcts and deep white matter hyperintensities. CADASIL is caused by mutations in NOTCH3 gene and is often overlooked and misdiagnosed. These patients generally present with migraine, stroke, transient ischemic attacks, cognitive impairment, and mood disorder symptoms to health clinics. This syndrome usually affects individuals in the fourth or fifth decade of their lives. Depression and mania were diagnosed in 20% and about 5% of these patients, respectively. The aim of this case report is to highlight bipolar clinical presentation of a quite young CADASIL case, as CADASIL is usually associated with psychiatric disorders in the elderly.

Key words: CADASIL, depression, mania


 
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REFERENCES
1. Kumral E, Tarlaci S. Vaskuler demanslar. NoroPsikiyatri Arþivi. 1999; 36: 90-96.
2. Narayan SK, Gorman G, Kalaria RN, Ford GA, Chinnery PF. The minimum prevalence of cadasil in England. Neurology. 2012; in press. [DOI via Crossref]   
3. Boussier Mg, Tournier- Lasserve E. Summary of the proceedings of the first International Workshop on CADASIL. Stroke. 1994; 25: 704-707.
4. Sabbadini G, Francia A, Calandriello L ve ark. Cerebral Autosomal Dominant Arteriopathy with subcortical infarcts and leukoencephalopathy. Brain. 1995; 118: 207-215 [DOI via Crossref]    [Pubmed]   
5. Mas JL, Dilouya A, de Recando J. A familial disorder with subcortical ischemic strokes, dementia and leukoencephalopathy. Neurology. 1992; 42: 1015-1019. [DOI via Crossref]    [Pubmed]   
6. Donnini I, Nannucci s, Valenti R, Pescini F, Bianchi S, Inzitari D, Pantoni L. Acetozolamide fort he migrain in Cadasil. J Headache Pain. 2012; inpress.
7. Monteiro C, Barros J, Tipa R, Pereira-Monteiro J. Sporadic hemiplegic migraine as the initial manifestation of Cadasil. Cephalalgia. 2012; 32: 255-257. [DOI via Crossref]    [Pubmed]   
8. Benisty S, Reyes S, Godin O, Herve D, Zieren N, Jouvent E, Zho Y, During M, Dichans M, Chabriat H. White matter lesions without lacuner infarcts in Cadasil. J Alzheimers Dis. 2012; in pres.
9. Dominquez-Sanchez FJ, Lasa-Aristu A, Gomi-Imizcoz M. Intelligence impairment, personality and psychopathology disturbances in a familiy affected with Cadasil. Span J Psychol. 2011; 14: 936-943. [DOI via Crossref]   
10. Chabriat H, Vahedi K, Ýba- Zizen MT ve ark. Clinical spectrum of CADASIL: a study of seven families. Lancet 1995; 346: 934-939. [DOI via Crossref]   
11. Penton AL, Leonard LD, Spinner NB. Notch signaling in human development and disease. Semin Cell Dev Biol. 2012; in pres.
12. Uchino M. The pathomechanism and treatment of CADASIL. Rinsho Shinkeigaku. 2011; 51: 945-948. [DOI via Crossref]    [Pubmed]   
13. Joutel A, Corpechot C, Ducros A ve ark. Notch3 mutations in CADASIL , a hereditary adult-onset condition causing stroke and dementia. Nature 1996; 383:707-710 [DOI via Crossref]    [Pubmed]   
14. Yuan P, Salvadore G, Li X ve ark. Valproate activates the Notch3/ cFlip signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life? Bipolar Disord 2009; 11(3): 256-269 [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
15. Reyes S, Kurtzs A, Herve D, Tournier-Lasserve E, Chabriat H. Presymptomatic genetic testing in CADASIL. J Neurol. 2012; in pres.
16. Gunda B, Herve D, Godin O, Bruno M, Reyes S, Alili N, Opherk C, Jouvent E, During M, Bousser MG, Dichgans M, Chabriat H. Effects of gender on the phenothype of CADASIL. Stroke. 2012; 43: 137-143. [DOI via Crossref]    [Pubmed]   
17. Kumar L, Mahr G. CADASIL Presenting as Bipolar Disorder. Psychosomatics 1997; 38: 397-398 [DOI via Crossref]   
18. Över MF. Migren baþagrili hastalarda beyaz cevher lezyonlarinin klinik ve laboratuar ozellikleri. Tez çaliþmasi. Çukurova Üniversitesi Tip Fakultesi. Adana 2008.
19. Aylward EH, Roberts- Twillie JV, Barta PE ve ark. Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. Am J Psychiatry. 1994; 151: 687-693 [Pubmed]   
20. Çakir S, Üçok A. Biliþsel bozukluk açisindan Þizofreni ve Bipolar Bozukluk. Noropsikiyatri Arþivi. 2010; 47: 150-157.
21. Brookes RL, Willis TA, Patel B, Morris RG, Markus HS. Depressive symptoms as apredictor of quality of life in cerebral small vessel disease. Int J Stroke. 2012; inpress.

This Article Cited By the following articles

Atypical Clinical Cases of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
Hum Physiol 2018; 44(8): 860.

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How to Cite this Article
Pubmed Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. [CADASIL syndrome presenting with bipolar disorder]. PBS. 2012; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716


Web Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. [CADASIL syndrome presenting with bipolar disorder]. https://www.pbsciences.org/?mno=9722 [Access: April 09, 2022]. Turkish. doi:10.5455/jmood.20120412113716


AMA (American Medical Association) Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. [CADASIL syndrome presenting with bipolar disorder]. PBS. 2012; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716



Vancouver/ICMJE Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. [CADASIL syndrome presenting with bipolar disorder]. PBS. (2012), [cited April 09, 2022]; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716



Harvard Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan (2012) [CADASIL syndrome presenting with bipolar disorder]. PBS, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716



Turabian Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. 2012. [CADASIL syndrome presenting with bipolar disorder]. Psychiatry and Behavioral Sciences, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716



Chicago Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. "[CADASIL syndrome presenting with bipolar disorder]." Psychiatry and Behavioral Sciences 2 (2012), 115-118. Turkish. doi:10.5455/jmood.20120412113716



MLA (The Modern Language Association) Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan. "[CADASIL syndrome presenting with bipolar disorder]." Psychiatry and Behavioral Sciences 2.3 (2012), 115-118. Print.Turkish. doi:10.5455/jmood.20120412113716



APA (American Psychological Association) Style

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıcaslan (2012) [CADASIL syndrome presenting with bipolar disorder]. Psychiatry and Behavioral Sciences, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716