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Case Report
Online Published: 30 Dec 2014
 


Valproic acid induced hyperammonaemic encephalopathy: case report

Gül Eryılmaz, Işıl Göğcegöz Gül, Barış Önen Ünsalver, Celal Salçini, Esra Sağlam.


Abstract
Hyperammonemia is a well-known adverse effect of valproic acid therapy. In the recent years, encephalopathy cases triggered by vaproic acid use-related hyperammonemia have been reported and regular blood ammonium level follow-up is suggested. Polypharmacy, malnutrition, urea cycle disorders are risk factors for encephalopathy triggered by vaproic acid related hyperammonemia. Here, we report a case of symptomatic non-hepatic encephalopathy during valproic acid treatment combined with electroconvulsive therapy (ECT). Valproic acid may have induced hyperammonemic encephalopathy in combination with the anesthetic agent propofol. We may suggest that patients receiving combination of valproic acid and propofol as induction agents for ECT, clinicians should be careful for the development of hyperammonaemic encephalopathy.

Key words: valproic Acid, non-hepatic encephalopathy, Propofol, electroconvulsive therapy


 
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How to Cite this Article
Pubmed Style

Eryılmaz G, Gul IG, Unsalver BO, Salcini C, Sağlam E. [Valproic acid induced hyperammonaemic encephalopathy: case report]. PBS. 2014; 4(4): 182-5. Turkish. doi:10.5455/jmood.20140414121325

Web Style

Eryılmaz G, Gul IG, Unsalver BO, Salcini C, Sağlam E. [Valproic acid induced hyperammonaemic encephalopathy: case report]. https://www.pbsciences.org/?mno=149983 [Access: April 05, 2025]. Turkish. doi:10.5455/jmood.20140414121325

AMA (American Medical Association) Style

Eryılmaz G, Gul IG, Unsalver BO, Salcini C, Sağlam E. [Valproic acid induced hyperammonaemic encephalopathy: case report]. PBS. 2014; 4(4): 182-5. Turkish. doi:10.5455/jmood.20140414121325


Vancouver/ICMJE Style

Eryılmaz G, Gul IG, Unsalver BO, Salcini C, Sağlam E. [Valproic acid induced hyperammonaemic encephalopathy: case report]. PBS. (2014), [cited April 05, 2025]; 4(4): 182-5. Turkish. doi:10.5455/jmood.20140414121325


Harvard Style

Eryılmaz, G., Gul, . I. G., Unsalver, . B. O., Salcini, . C. & Sağlam, . E. (2014) [Valproic acid induced hyperammonaemic encephalopathy: case report]. PBS, 4 (4), 182-5. Turkish. doi:10.5455/jmood.20140414121325


Turabian Style

Eryılmaz, Gul, Işıl Goğcegoz Gul, Barış Onen Unsalver, Celal Salcini, and Esra Sağlam. 2014. [Valproic acid induced hyperammonaemic encephalopathy: case report]. Psychiatry and Behavioral Sciences, 4 (4), 182-5. Turkish. doi:10.5455/jmood.20140414121325


Chicago Style

Eryılmaz, Gul, Işıl Goğcegoz Gul, Barış Onen Unsalver, Celal Salcini, and Esra Sağlam. "[Valproic acid induced hyperammonaemic encephalopathy: case report]." Psychiatry and Behavioral Sciences 4 (2014), 182-5. Turkish. doi:10.5455/jmood.20140414121325


MLA (The Modern Language Association) Style

Eryılmaz, Gul, Işıl Goğcegoz Gul, Barış Onen Unsalver, Celal Salcini, and Esra Sağlam. "[Valproic acid induced hyperammonaemic encephalopathy: case report]." Psychiatry and Behavioral Sciences 4.4 (2014), 182-5. Print.Turkish. doi:10.5455/jmood.20140414121325


APA (American Psychological Association) Style

Eryılmaz, G., Gul, . I. G., Unsalver, . B. O., Salcini, . C. & Sağlam, . E. (2014) [Valproic acid induced hyperammonaemic encephalopathy: case report]. Psychiatry and Behavioral Sciences, 4 (4), 182-5. Turkish. doi:10.5455/jmood.20140414121325


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