E-ISSN 2636-834X
 

Original Research 


Investigation of Irisin Levels in Patients with Major Depressive Disorder

Burak Okumuş, Meltem Pusuroğlu, Mehmet Baltacıoğlu, İlkay Bahçeci, Bülent Bahçeci.


Abstract
Objective: Major depressive disorder (MDD) is a common psychiatric disorder. Irisin, produced by proteolysis of FNDC5, is thought to be an exercise-induced hormone that may play a critical role in inducing antidepressant-like effects. Our study aimed to investigate the relationship between irisin and newly diagnosed MDD patients.

Methods: This cross-sectional study included 85 first-time diagnosed MDD patients and 81 healthy controls. Patients were diagnosed with MDD using the Structured Clinical Interview Questionnaire for DSM-IV Axis I and II Disorders (SCID-I, II) and the Hamilton Depression Scale (HAM-D). After an overnight fast, 5 ml of peripheral blood was drawn and serum irisin levels were measured.

Results: When the effects of age and gender variables were controlled, no statistically significant difference in irisin levels was found between the groups. (F=1.832, p=0.178). When the effects of age, gender and body mass index variables were controlled and a partial correlation was made between irisin and HAMD scores, a significant negative correlation was found between irisin and HAMD scores (p<0.001, r=-0.523). The correlation analysis showed a statistically significant negative relationship between age and irisin levels (p=0.008, r=-0.205). However, when the effects of other variables were controlled and a partial correlation was made, no statistically significant relationship was found (p=0.610, r=-0.207).

Conclusion: Our results indicate that irisin levels are associated with the severity of depression. Further studies are needed on the use of irisin as a potential biomarker for predicting clinical course and treatment response in patients with severe MDD.

Key words: Major Depressive Disorder, Irisin, Etiopathogenesis


 
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How to Cite this Article
Pubmed Style

Okumuş B, Pusuroğlu M, Baltacıoğlu M, Bahceci , Bahceci B. Investigation of Irisin Levels in Patients with Major Depressive Disorder. PBS. 2024; 14(1): 40-47. doi:10.5455/PBS.20230914073554


Web Style

Okumuş B, Pusuroğlu M, Baltacıoğlu M, Bahceci , Bahceci B. Investigation of Irisin Levels in Patients with Major Depressive Disorder. https://www.pbsciences.org/?mno=169416 [Access: April 07, 2024]. doi:10.5455/PBS.20230914073554


AMA (American Medical Association) Style

Okumuş B, Pusuroğlu M, Baltacıoğlu M, Bahceci , Bahceci B. Investigation of Irisin Levels in Patients with Major Depressive Disorder. PBS. 2024; 14(1): 40-47. doi:10.5455/PBS.20230914073554



Vancouver/ICMJE Style

Okumuş B, Pusuroğlu M, Baltacıoğlu M, Bahceci , Bahceci B. Investigation of Irisin Levels in Patients with Major Depressive Disorder. PBS. (2024), [cited April 07, 2024]; 14(1): 40-47. doi:10.5455/PBS.20230914073554



Harvard Style

Okumuş, B., Pusuroğlu, . M., Baltacıoğlu, . M., Bahceci, . . & Bahceci, . B. (2024) Investigation of Irisin Levels in Patients with Major Depressive Disorder. PBS, 14 (1), 40-47. doi:10.5455/PBS.20230914073554



Turabian Style

Okumuş, Burak, Meltem Pusuroğlu, Mehmet Baltacıoğlu, İlkay Bahceci, and Bulent Bahceci. 2024. Investigation of Irisin Levels in Patients with Major Depressive Disorder. Psychiatry and Behavioral Sciences, 14 (1), 40-47. doi:10.5455/PBS.20230914073554



Chicago Style

Okumuş, Burak, Meltem Pusuroğlu, Mehmet Baltacıoğlu, İlkay Bahceci, and Bulent Bahceci. "Investigation of Irisin Levels in Patients with Major Depressive Disorder." Psychiatry and Behavioral Sciences 14 (2024), 40-47. doi:10.5455/PBS.20230914073554



MLA (The Modern Language Association) Style

Okumuş, Burak, Meltem Pusuroğlu, Mehmet Baltacıoğlu, İlkay Bahceci, and Bulent Bahceci. "Investigation of Irisin Levels in Patients with Major Depressive Disorder." Psychiatry and Behavioral Sciences 14.1 (2024), 40-47. Print. doi:10.5455/PBS.20230914073554



APA (American Psychological Association) Style

Okumuş, B., Pusuroğlu, . M., Baltacıoğlu, . M., Bahceci, . . & Bahceci, . B. (2024) Investigation of Irisin Levels in Patients with Major Depressive Disorder. Psychiatry and Behavioral Sciences, 14 (1), 40-47. doi:10.5455/PBS.20230914073554