E-ISSN 2636-834X
 

Original Research 


Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas.

Abstract
Objective: In recent years besides dopaminergic imbalance exhibition of other possible mechanisms like inflammation and serotonergic abnormalities have pointed out the need for new antipsychotic drugs. In this study our aim was investigating the effects of atorvastatin and melatonin in experimental psychosis model in rats.
Materyal and Methods: Apomorphine-induced stereotypy has been used as a convenient method for in vivo screening of dopamine agonists or antagonists, and assessment of dopaminergic activity. All rats were observed and assessed singly in the Plexiglas cage, 7 (n=6) groups of rat were administered atorvastatin (10, 20 mg/kg, i.p.), melatonin (10, 20 mg/kg, i.p.), 1% ethanol sham (1 ml/kg, i.p.) chlorpromazine (1 mg/kg; i.p.) or isotonic NaCl (1 ml/kg, i.p.). After apomorphine administration, the rats were immediately placed back into the metal cages and observed for stereotypic and rearing behaviors for 15 minutes.
Results: Whereas 20 mg/kg of atorvastatin and 20 mg/kg of melatonin decreased rearing behavior scores compared to saline group significantly (p<0.05). 10 mg/kg of atorvastatin and 20 mg/kg of melatonin groups had decreased stereotypy scores (p<0.05), but 20 mg/kg of atorvastatin caused a stronger decrease (p<0.001).
Conclusions: In the clinical practice when antipsychotic’s side effects and non-satisfactory treatment options are regarded, it is obvious that new drugs like atorvastatin and melatonin with different mechanisms (like anti-inflammatory, neuroprotective effects) of actions will enlighten the future studies.

Key words: psychosis, statin, melatonin, stereotypy


 
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How to Cite this Article
Pubmed Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. PBS. 2015; 5(3): 120-5. doi:10.5455/jmood.20150714014531


Web Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. https://www.pbsciences.org/?mno=178892 [Access: December 15, 2023]. doi:10.5455/jmood.20150714014531


AMA (American Medical Association) Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. PBS. 2015; 5(3): 120-5. doi:10.5455/jmood.20150714014531



Vancouver/ICMJE Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. PBS. (2015), [cited December 15, 2023]; 5(3): 120-5. doi:10.5455/jmood.20150714014531



Harvard Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas (2015) Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. PBS, 5 (3), 120-5. doi:10.5455/jmood.20150714014531



Turabian Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. 2015. Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. Psychiatry and Behavioral Sciences, 5 (3), 120-5. doi:10.5455/jmood.20150714014531



Chicago Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. "Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats." Psychiatry and Behavioral Sciences 5 (2015), 120-5. doi:10.5455/jmood.20150714014531



MLA (The Modern Language Association) Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas. "Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats." Psychiatry and Behavioral Sciences 5.3 (2015), 120-5. Print. doi:10.5455/jmood.20150714014531



APA (American Psychological Association) Style

Volkan Solmaz, Dursun Delibas, Sema Inanir, Oytun Erbas (2015) Antipsychotic like effects of atorvastatin and melatonin in a psychosis model in rats. Psychiatry and Behavioral Sciences, 5 (3), 120-5. doi:10.5455/jmood.20150714014531