E-ISSN 2636-834X
 

Original Research 


The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio

Fatih Canan, Nehir Kürklü, Ömer Geçici, Murat Kuloğlu.

Abstract
Objective: Inflammatory and immune mechanisms are reported to play important roles in the pathophysiology of psychiatric disorders. Electroconvulsive therapy (ECT) is regarded as an effective treatment of not only depression, but also schizophrenia and mania, especially when there is no response to pharmacological interventions. Despite the common use of ECT, its mechanism of action is mostly unknown. Few studies examined the effect of ECT on inflammatory and immune functions. The neutrophil–lymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our aim was to investigate whether a series of ECT sessions would change NLR in patients with major depression, bipolar disorder, or schizophrenia.
Method: In this retrospective study, we analyzed 61 patients (unipolar depression, n=35; acute mania n=13; and schizophrenia, n=13). Complete blood count measurements were recorded before and after repeated ECT treatment.
Results: We found no difference in NLR between before (2.27±2.54) and after (2.49±1.65) repetaed ECT treatments (p>0.05). Furthermore, a series of ECT did not change NLR in seperate diagnostic groups.
Conclusions: To our knowledge, this is the first study to evaluate the impact of ECT on NLR. Our findings suggest that NLR levels are not altered after repeated ECT treatments.

Key words: electroconvulsive therapy, neutrophil/lymphocyte ratio, inflammation, immunology


 
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How to Cite this Article
Pubmed Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. PBS. 2016; 6(1): 1-6. Turkish. doi:10.5455/jmood.20160218093328


Web Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. https://www.pbsciences.org/?mno=215076 [Access: December 15, 2023]. Turkish. doi:10.5455/jmood.20160218093328


AMA (American Medical Association) Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. PBS. 2016; 6(1): 1-6. Turkish. doi:10.5455/jmood.20160218093328



Vancouver/ICMJE Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. PBS. (2016), [cited December 15, 2023]; 6(1): 1-6. Turkish. doi:10.5455/jmood.20160218093328



Harvard Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu (2016) [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. PBS, 6 (1), 1-6. Turkish. doi:10.5455/jmood.20160218093328



Turabian Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. 2016. [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. Psychiatry and Behavioral Sciences, 6 (1), 1-6. Turkish. doi:10.5455/jmood.20160218093328



Chicago Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. "[The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]." Psychiatry and Behavioral Sciences 6 (2016), 1-6. Turkish. doi:10.5455/jmood.20160218093328



MLA (The Modern Language Association) Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu. "[The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]." Psychiatry and Behavioral Sciences 6.1 (2016), 1-6. Print.Turkish. doi:10.5455/jmood.20160218093328



APA (American Psychological Association) Style

Fatih Canan, Nehir Kurklu, Omer Gecici, Murat Kuloğlu (2016) [The effect of electroconvulsive therapy on neutrophyl/lymphocyte ratio]. Psychiatry and Behavioral Sciences, 6 (1), 1-6. Turkish. doi:10.5455/jmood.20160218093328