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Letter to the Editor
Online Published: 30 Jun 2016
 


Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?

Alejandro Barquero Madrigal.


Abstract
Rebound syndromes are well described among several drugs, not only psychotropics. A key element to suspect them is that full manifestations of this phenomenon occur after a given period that depends on the drug´s half-life. Strictly within antipsychotics and their M1 cholinergic receptor blockade, switching from a high- to a low-affinity drug can induce cholinergic rebound, with symptoms like malaise, nausea, vomiting, diarrhea, sialorrhea, extrapyramidal symptoms and akathisia. We know, for example, that abrupt clozapine withdrawal has been associated with cholinergic rebound as well as with serotonin syndrome. PubMed database (last search on 02/15/2016, search terms “cholinergic rebound AND antipsychotics”, with no time limit) shows 27 results for this topic: 04 case reports, 09 review articles, and 02 randomized controlled trials (only one specifically for cholinergic rebound). In the current case, cholinergic symptoms were observed while switching between typical antipsychotics.

Key words: Rebound syndromes, cholinergic rebound, antipsychotics, side effects.


 
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How to Cite this Article
Pubmed Style

Alejandro Barquero Madrigal. Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. PBS. 2016; 6(2): 88-90. doi:10.5455/jmood.20160306114254

Web Style

Alejandro Barquero Madrigal. Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. https://www.pbsciences.org/?mno=215496 [Access: September 13, 2024]. doi:10.5455/jmood.20160306114254

AMA (American Medical Association) Style

Alejandro Barquero Madrigal. Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. PBS. 2016; 6(2): 88-90. doi:10.5455/jmood.20160306114254


Vancouver/ICMJE Style

Alejandro Barquero Madrigal. Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. PBS. (2016), [cited September 13, 2024]; 6(2): 88-90. doi:10.5455/jmood.20160306114254


Harvard Style

Alejandro Barquero Madrigal (2016) Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. PBS, 6 (2), 88-90. doi:10.5455/jmood.20160306114254


Turabian Style

Alejandro Barquero Madrigal. 2016. Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. Psychiatry and Behavioral Sciences, 6 (2), 88-90. doi:10.5455/jmood.20160306114254


Chicago Style

Alejandro Barquero Madrigal. "Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?." Psychiatry and Behavioral Sciences 6 (2016), 88-90. doi:10.5455/jmood.20160306114254


MLA (The Modern Language Association) Style

Alejandro Barquero Madrigal. "Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?." Psychiatry and Behavioral Sciences 6.2 (2016), 88-90. Print. doi:10.5455/jmood.20160306114254


APA (American Psychological Association) Style

Alejandro Barquero Madrigal (2016) Motor Symptoms While Switching Antipsychotics: Should We Taper or Increase The Dose?. Psychiatry and Behavioral Sciences, 6 (2), 88-90. doi:10.5455/jmood.20160306114254


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Address: Bagdat Cad. Birgen Is Merkezi 226/7 Kadikoy - Istanbul - TURKEY 34728Phone:+90 (532) 272 32 52E-mail:psikofarmakoloji@gmail.com