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2025, Vol: 15, Issue: 4
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Review Article 


Bipolar disorder and inflammation

Tevfik Kalelioğlu, Abdullah Genç, Nesrin Karamustafalıoğlu.


Abstract
There is growing number of researches showing evidence about the role of inflammation in pathophysiology of bipolar disorder. Besides inflammation in central nervous system, systemic inflammation is also thought to be associated with the acute and euthymic episodes and clinical outcome of illness. In this reviewö we firstly focus on the quantitative and structural changes in immune cells and their relationship with the illness episodes. Also cytokines, which have an important role in inflammation and are measurable in systemic circulation, are summarized. In addition to changes of inflammatory markers in different episodes of bipolar disorder, we mention the effect of bipolar disorder treatments on these markers. Acute phase proteins, which are produced and induced by the effect of cytokines, are also reviewed. Finally, we discuss the role of anti-inflammatory agents in treatment of bipolar disorder and offer suggestions about future researches.

Key words: bipolar disorder, inflammation, cytokines, immune system, inflammatory biomarkers


 
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How to Cite this Article
Pubmed Style

Kalelioğlu T, Genc A, Karamustafalıoğlu N. [Bipolar disorder and inflammation]. PBS. 2017; 7(1): 54-64. Turkish. doi:10.5455/jmood.20170203100427

Web Style

Kalelioğlu T, Genc A, Karamustafalıoğlu N. [Bipolar disorder and inflammation]. https://www.pbsciences.org/?mno=230938 [Access: November 10, 2025]. Turkish. doi:10.5455/jmood.20170203100427

AMA (American Medical Association) Style

Kalelioğlu T, Genc A, Karamustafalıoğlu N. [Bipolar disorder and inflammation]. PBS. 2017; 7(1): 54-64. Turkish. doi:10.5455/jmood.20170203100427


Vancouver/ICMJE Style

Kalelioğlu T, Genc A, Karamustafalıoğlu N. [Bipolar disorder and inflammation]. PBS. (2017), [cited November 10, 2025]; 7(1): 54-64. Turkish. doi:10.5455/jmood.20170203100427


Harvard Style

Kalelioğlu, T., Genc, . A. & Karamustafalıoğlu, . N. (2017) [Bipolar disorder and inflammation]. PBS, 7 (1), 54-64. Turkish. doi:10.5455/jmood.20170203100427


Turabian Style

Kalelioğlu, Tevfik, Abdullah Genc, and Nesrin Karamustafalıoğlu. 2017. [Bipolar disorder and inflammation]. Psychiatry and Behavioral Sciences, 7 (1), 54-64. Turkish. doi:10.5455/jmood.20170203100427


Chicago Style

Kalelioğlu, Tevfik, Abdullah Genc, and Nesrin Karamustafalıoğlu. "[Bipolar disorder and inflammation]." Psychiatry and Behavioral Sciences 7 (2017), 54-64. Turkish. doi:10.5455/jmood.20170203100427


MLA (The Modern Language Association) Style

Kalelioğlu, Tevfik, Abdullah Genc, and Nesrin Karamustafalıoğlu. "[Bipolar disorder and inflammation]." Psychiatry and Behavioral Sciences 7.1 (2017), 54-64. Print.Turkish. doi:10.5455/jmood.20170203100427


APA (American Psychological Association) Style

Kalelioğlu, T., Genc, . A. & Karamustafalıoğlu, . N. (2017) [Bipolar disorder and inflammation]. Psychiatry and Behavioral Sciences, 7 (1), 54-64. Turkish. doi:10.5455/jmood.20170203100427


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Prof. Dr. Muhammed Tayyib Kadak
Address: Istanbul University-Cerrahpaşa Cerrahpaşa Campus, Kocamustafapaşa Street No:53, Cerrahpaşa, 34098, Fatih - Istanbul, TURKIYE
E-mail:muhammedtayyib.kadak@iuc.edu.tr