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Case Report 


Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment

Ismail Akaltun, Hamza Ayaydin, Tayfun Kara.

Abstract
Attention-deficit/ hyperactivity disorder is one of the most commonly observed pediatric psychiatric disorders in today’s child and adolescent psychiatry clinics. Methylphenidate (MPH), a psychostimulant that acts on the dopaminergic system, is frequently used in treatment. Several studies have been performed concerning hiccups, and although some neurological mechanisms have been described, the pathophysiology is still unclear. However, neurotransmitter changes and hypo-/hyperdopaminergic states are known to lead to hiccups. A 7-year-old boy was brought by his parents to our clinic due to hyperactivity, inability to remain still, frequent boredom, and compulsive talking. ADHD was diagnosed on the basis of DSM-5 diagnostic criteria following psychiatric assessments, and MPH was initiated. Hiccups had developed and persisting 3-4 hours after medication administration. Hiccups had resumed when the drug was administered again, and stopped after 3-4 hours. Resolution in cases of hiccups treated with MPH is probably associated with improvement of a hypodopaminergic state through MPH raising dopamine levels. Additionally, we think that MPH can also trigger hiccups (as in our case) by causing a hyperdopaminergic state. We therefore think that further studies are needed in order to clarify the etiology of hiccups and the relationship with drug interactions.

Key words: Attention-deficit/ hyperactivity disorder, hiccup, methylphenidate, child


 
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How to Cite this Article
Pubmed Style

Akaltun I, Ayaydin H, Kara T. Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. PBS. 2018; 8(2): 86-9. doi:10.5455/jmood.20180102010747


Web Style

Akaltun I, Ayaydin H, Kara T. Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. https://www.pbsciences.org/?mno=287144 [Access: December 15, 2023]. doi:10.5455/jmood.20180102010747


AMA (American Medical Association) Style

Akaltun I, Ayaydin H, Kara T. Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. PBS. 2018; 8(2): 86-9. doi:10.5455/jmood.20180102010747



Vancouver/ICMJE Style

Akaltun I, Ayaydin H, Kara T. Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. PBS. (2018), [cited December 15, 2023]; 8(2): 86-9. doi:10.5455/jmood.20180102010747



Harvard Style

Akaltun, I., Ayaydin, . H. & Kara, . T. (2018) Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. PBS, 8 (2), 86-9. doi:10.5455/jmood.20180102010747



Turabian Style

Akaltun, Ismail, Hamza Ayaydin, and Tayfun Kara. 2018. Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. Psychiatry and Behavioral Sciences, 8 (2), 86-9. doi:10.5455/jmood.20180102010747



Chicago Style

Akaltun, Ismail, Hamza Ayaydin, and Tayfun Kara. "Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment." Psychiatry and Behavioral Sciences 8 (2018), 86-9. doi:10.5455/jmood.20180102010747



MLA (The Modern Language Association) Style

Akaltun, Ismail, Hamza Ayaydin, and Tayfun Kara. "Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment." Psychiatry and Behavioral Sciences 8.2 (2018), 86-9. Print. doi:10.5455/jmood.20180102010747



APA (American Psychological Association) Style

Akaltun, I., Ayaydin, . H. & Kara, . T. (2018) Hiccups in Attention-Deficit/ Hyperactivity Disorder Under Methylphenidate Treatment. Psychiatry and Behavioral Sciences, 8 (2), 86-9. doi:10.5455/jmood.20180102010747