Lack of association between COMT gene polymorphism and treatment outcome in major depression

Salih Selek; Mehmet C. Kaya; Mehmet Emin Erdal; Mahmut Bulut; Murat Eren Ozen; Mehmet Yumru; Ömer Barlas; Aysun Kalenderoglu; Hasan Herken

2025, Vol: 15, Issue: 1

15 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

Required files to be uploaded

COPYRIGHT FORM
_Title_Page_Obligatory_(v2r)_

« Previous Article

Original Research

PBS. 2011; 1(1): 19-24

Lack of association between COMT gene polymorphism and treatment outcome in major depression

Salih Selek, Mehmet C. Kaya, Mehmet Emin Erdal, Mahmut Bulut, Murat Eren Ozen, Mehmet Yumru, Ömer Barlas, Aysun Kalenderoglu, Hasan Herken.

Abstract
Background & Aim: Abnormal activity of Catechol-O-methyl transferase (COMT), as a major degrading enzyme of catecholaminergic neurotransmitters may be enrolled in the pathogenesis of mood disorders. The aim of this study was to investigate the association between COMT genetic polymorphism and major depression patients.
Method: The study included 137 unrelated major depressive disorder (MDD) patients and 153 healthy unrelated controls, all were of Turkish origin. The patients were treated with antidepressant drugs for 8 weeks. All patients were assessed by Hamilton Depression Rating Scale (HDRS) before and after the antidepressant treatment. The analysis of COMT G1947A polymorphism was performed using PCR based endonuclease digestion method.
Results: No significant difference was found between MDD and control subjects. In the MDD patients, there was no relationship between duration of illness, and pretreatment HDRS scores in respect to COMT gene polymorphism. The distribution of COMT genotypes and alleles was not significantly different among the controls and MDD patients.
Conclusion: Our findings indicated that distribution of COMT genetic polymorphism were not different significantly between the patients and controls. No allele was found to be a predictor for treatment outcome by antidepressant therapy or for clinical manifestations in MDD.

Key words: COMT gene, antidepressant treatment response, gender, major depression, polymorphism

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Salih Selek Articles by Mehmet C. Kaya Articles by Mehmet Emin Erdal Articles by Mahmut Bulut Articles by Murat Eren Ozen Articles by Mehmet Yumru Articles by Ömer Barlas Articles by Aysun Kalenderoglu Articles by Hasan Herken
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Selek S, Kaya MC, Erdal ME, Bulut M, Ozen ME, Yumru M, Barlas O, Kalenderoglu A, Herken H. Lack of association between COMT gene polymorphism and treatment outcome in major depression. PBS. 2011; 1(1): 19-24.

Web Style

Selek S, Kaya MC, Erdal ME, Bulut M, Ozen ME, Yumru M, Barlas O, Kalenderoglu A, Herken H. Lack of association between COMT gene polymorphism and treatment outcome in major depression. https://www.pbsciences.org/?mno=7525 [Access: April 06, 2025].

AMA (American Medical Association) Style

Selek S, Kaya MC, Erdal ME, Bulut M, Ozen ME, Yumru M, Barlas O, Kalenderoglu A, Herken H. Lack of association between COMT gene polymorphism and treatment outcome in major depression. PBS. 2011; 1(1): 19-24.

Vancouver/ICMJE Style

Harvard Style

Selek, S., Kaya, . M. C., Erdal, . M. E., Bulut, . M., Ozen, . M. E., Yumru, . M., Barlas, . O., Kalenderoglu, . A. & Herken, . H. (2011) Lack of association between COMT gene polymorphism and treatment outcome in major depression. PBS, 1 (1), 19-24.

Turabian Style

Selek, Salih, Mehmet C. Kaya, Mehmet Emin Erdal, Mahmut Bulut, Murat Eren Ozen, Mehmet Yumru, Omer Barlas, Aysun Kalenderoglu, and Hasan Herken. 2011. Lack of association between COMT gene polymorphism and treatment outcome in major depression. Psychiatry and Behavioral Sciences, 1 (1), 19-24.

Chicago Style

Selek, Salih, Mehmet C. Kaya, Mehmet Emin Erdal, Mahmut Bulut, Murat Eren Ozen, Mehmet Yumru, Omer Barlas, Aysun Kalenderoglu, and Hasan Herken. "Lack of association between COMT gene polymorphism and treatment outcome in major depression." Psychiatry and Behavioral Sciences 1 (2011), 19-24.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Author Login Reviewer Login

About Psychiatry and Behavioral Sciences

Contact Information

How to cite this article