Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder

Süleyman Demir; Mahmut Bulut; Mehmet Cemal Kaya; Bünyamin Sevim; Özlem Demirpençe; Aslıhan Okan İbiloğlu; Mehmet Güneş; Abdullah Atli; Yasin Bez

doi:10.5455/jmood.20150929074204

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Online Published: 04 Dec 2015

PBS. 2015; 5(4): 145-50

doi: 10.5455/jmood.20150929074204

Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder

Süleyman Demir, Mahmut Bulut, Mehmet Cemal Kaya, Bünyamin Sevim, Özlem Demirpençe, Aslıhan Okan İbiloğlu, Mehmet Güneş, Abdullah Atli, Yasin Bez.

Abstract
Objective: It was reported that High Mobility Group Box 1 (HMGB1), also known as the nuclear transcription factor, is a late mediator of inflammation. It was thought that HMGB1 has a prominent role in the activation of Tumor Necrosis Factor-? (TNF-?), Interleukin (IL)-1ß and IL-8 which are proinflammatory mediators during inflammation. HMGB1 plays a role in progress, diagnosis and prognosis of immune system illnesses. Besides suppressing the immune system, Major Depressive Disorder (MDD) was indicated to cause changes in inflammatory processes. Biological determinants affecting the diagnosis, therapy, and prognosis of depression are quite limited. Therefore, new etiological models are needed to explain the pathophysiology of depression. There is no study in the literature investigating level of HMGB1 in MDD of the humans. This study aims to examine the role of inflammation in the etiology of depression based on the HMGB1 in patients with MDD.
Methods: A total of 30 patients diagnosed with MDD were included in the study. The control group consisted of 30 healthy subjects without any psychiatric disorders. A socio-demographic information form, Hamilton Depression Rating Scale (HDRS) and Clinical Global Impression Scale (CGIS) were administered, and blood was taken for measurement of HMGB1 levels.
Results: Significantly higher HMGB1 values were identified with the patient group when compared to the control group (p<0.05).
Conclusion: Our study is the first in which HMGB1 level was investigated in MDD ot the humans. The findings of the study reveal that HMGB1 tends to be higher in patients with MDD, and a high HMGB1 value supports the view that inflammation might have a critical role in the etiology of MDD.

Key words: major depressive disorder, High Mobility Group Box-1, inflammation

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How to Cite this Article

Pubmed Style

Demir S, Bulut M, Kaya MC, Sevim B, Demirpence O, İbiloğlu AO, Guneş M, Atli A, Bez Y. [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. PBS. 2015; 5(4): 145-50. Turkish. doi:10.5455/jmood.20150929074204

Web Style

Demir S, Bulut M, Kaya MC, Sevim B, Demirpence O, İbiloğlu AO, Guneş M, Atli A, Bez Y. [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. https://www.pbsciences.org/?mno=199040 [Access: June 22, 2026]. Turkish. doi:10.5455/jmood.20150929074204

AMA (American Medical Association) Style

Demir S, Bulut M, Kaya MC, Sevim B, Demirpence O, İbiloğlu AO, Guneş M, Atli A, Bez Y. [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. PBS. 2015; 5(4): 145-50. Turkish. doi:10.5455/jmood.20150929074204

Vancouver/ICMJE Style

Demir S, Bulut M, Kaya MC, Sevim B, Demirpence O, İbiloğlu AO, Guneş M, Atli A, Bez Y. [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. PBS. (2015), [cited June 22, 2026]; 5(4): 145-50. Turkish. doi:10.5455/jmood.20150929074204

Harvard Style

Demir, S., Bulut, . M., Kaya, . M. C., Sevim, . B., Demirpence, . O., İbiloğlu, . A. O., Guneş, . M., Atli, . A. & Bez, . Y. (2015) [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. PBS, 5 (4), 145-50. Turkish. doi:10.5455/jmood.20150929074204

Turabian Style

Demir, Suleyman, Mahmut Bulut, Mehmet Cemal Kaya, Bunyamin Sevim, Ozlem Demirpence, Aslıhan Okan İbiloğlu, Mehmet Guneş, Abdullah Atli, and Yasin Bez. 2015. [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. Psychiatry and Behavioral Sciences, 5 (4), 145-50. Turkish. doi:10.5455/jmood.20150929074204

Chicago Style

Demir, Suleyman, Mahmut Bulut, Mehmet Cemal Kaya, Bunyamin Sevim, Ozlem Demirpence, Aslıhan Okan İbiloğlu, Mehmet Guneş, Abdullah Atli, and Yasin Bez. "[Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]." Psychiatry and Behavioral Sciences 5 (2015), 145-50. Turkish. doi:10.5455/jmood.20150929074204

MLA (The Modern Language Association) Style

Demir, Suleyman, Mahmut Bulut, Mehmet Cemal Kaya, Bunyamin Sevim, Ozlem Demirpence, Aslıhan Okan İbiloğlu, Mehmet Guneş, Abdullah Atli, and Yasin Bez. "[Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]." Psychiatry and Behavioral Sciences 5.4 (2015), 145-50. Print.Turkish. doi:10.5455/jmood.20150929074204

APA (American Psychological Association) Style

Demir, S., Bulut, . M., Kaya, . M. C., Sevim, . B., Demirpence, . O., İbiloğlu, . A. O., Guneş, . M., Atli, . A. & Bez, . Y. (2015) [Increased High Mobility Group Box1 (HMGB1) level in major depressive disorder]. Psychiatry and Behavioral Sciences, 5 (4), 145-50. Turkish. doi:10.5455/jmood.20150929074204

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