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Case Report
Online Published: 30 Sep 2012
 


CADASIL syndrome presenting with bipolar disorder

Sermin Kesebir, Esra Kaymak Koca, Esin Evren Kılıçaslan.


Abstract
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), a small vessel disease, is characterized with subcortical infarcts and deep white matter hyperintensities. CADASIL is caused by mutations in NOTCH3 gene and is often overlooked and misdiagnosed. These patients generally present with migraine, stroke, transient ischemic attacks, cognitive impairment, and mood disorder symptoms to health clinics. This syndrome usually affects individuals in the fourth or fifth decade of their lives. Depression and mania were diagnosed in 20% and about 5% of these patients, respectively. The aim of this case report is to highlight bipolar clinical presentation of a quite young CADASIL case, as CADASIL is usually associated with psychiatric disorders in the elderly.

Key words: CADASIL, depression, mania


 
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How to Cite this Article
Pubmed Style

Kesebir S, Koca EK, Kılıcaslan EE. [CADASIL syndrome presenting with bipolar disorder]. PBS. 2012; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716

Web Style

Kesebir S, Koca EK, Kılıcaslan EE. [CADASIL syndrome presenting with bipolar disorder]. https://www.pbsciences.org/?mno=9722 [Access: June 22, 2026]. Turkish. doi:10.5455/jmood.20120412113716

AMA (American Medical Association) Style

Kesebir S, Koca EK, Kılıcaslan EE. [CADASIL syndrome presenting with bipolar disorder]. PBS. 2012; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716


Vancouver/ICMJE Style

Kesebir S, Koca EK, Kılıcaslan EE. [CADASIL syndrome presenting with bipolar disorder]. PBS. (2012), [cited June 22, 2026]; 2(3): 115-118. Turkish. doi:10.5455/jmood.20120412113716


Harvard Style

Kesebir, S., Koca, . E. K. & Kılıcaslan, . E. E. (2012) [CADASIL syndrome presenting with bipolar disorder]. PBS, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716


Turabian Style

Kesebir, Sermin, Esra Kaymak Koca, and Esin Evren Kılıcaslan. 2012. [CADASIL syndrome presenting with bipolar disorder]. Psychiatry and Behavioral Sciences, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716


Chicago Style

Kesebir, Sermin, Esra Kaymak Koca, and Esin Evren Kılıcaslan. "[CADASIL syndrome presenting with bipolar disorder]." Psychiatry and Behavioral Sciences 2 (2012), 115-118. Turkish. doi:10.5455/jmood.20120412113716


MLA (The Modern Language Association) Style

Kesebir, Sermin, Esra Kaymak Koca, and Esin Evren Kılıcaslan. "[CADASIL syndrome presenting with bipolar disorder]." Psychiatry and Behavioral Sciences 2.3 (2012), 115-118. Print.Turkish. doi:10.5455/jmood.20120412113716


APA (American Psychological Association) Style

Kesebir, S., Koca, . E. K. & Kılıcaslan, . E. E. (2012) [CADASIL syndrome presenting with bipolar disorder]. Psychiatry and Behavioral Sciences, 2 (3), 115-118. Turkish. doi:10.5455/jmood.20120412113716


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