Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state

Berna Ermis; Eser Sagaltici; Ahmet Unal; Demet Alici; Ayse Binnur Ozyurt

doi:10.5455/PBS.20210610075010

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Original Research

PBS. 2021; 11(4): 249-257

doi: 10.5455/PBS.20210610075010

Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state

Berna Ermis, Eser Sagaltici, Ahmet Unal, Demet Alici, Ayse Binnur Ozyurt.

Abstract
Objective: This study aimed to investigate oxidative metabolism and oxidative DNA damage in the state of euthymic and active disease in patients with Bipolar disorder (BD).
Methods: 40 active (26 mania and14 depression episodes) and 40 euthymic state of disease of the 80 patients with BD and 48 healthy volunteers were included to the study. Measurement of the levels of serum total antioxidant (TAS) and serum total oxidant (TOS), Oxidative Stress Index (OSI), and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels were calculated and evaluated. Hamilton Depression Rating Scale (HAM-D), Young Mania Rating Scale (YMRS) and Clinical Global Impression Scale (CGI) were administered.
Results: In patients with BD, TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). TOS level significantly higher in female than men in BD (p=0.016). A significantly positive weak correlation was detected between the TAS level and CGI score (p=0.031, r=0.241), HAM-D score (p=0.040, r=0.231) in BD. When patients in the active and euthymic state were compared with the control group separately, in both groups TAS, TOS, OSI, and 8-OHdG levels were significantly higher than controls (all p<0.001). However, there was no significant difference in TOS, OSI, and 8-OHdG levels between patients in the active or euthymic state of disease.
Conclusions: Oxidants and DNA damage are high in patient with BD. No difference of the oxidants and DNA damage between the active and euthymic state of disease reveals that oxidative stress damages on the body although the symptoms of the disease to quiet down.

Key words: Bipolar disorder, oxidative stress, level of total antioxidant, level of total oxidant, oxidative DNA damage, 8-hydroxydeoxyguanosine.

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Pubmed Style

Ermis B, Sagaltici E, Unal A, Alici D, Ozyurt AB. Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. PBS. 2021; 11(4): 249-257. doi:10.5455/PBS.20210610075010

Web Style

Ermis B, Sagaltici E, Unal A, Alici D, Ozyurt AB. Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. https://www.pbsciences.org/?mno=87259 [Access: September 13, 2024]. doi:10.5455/PBS.20210610075010

AMA (American Medical Association) Style

Ermis B, Sagaltici E, Unal A, Alici D, Ozyurt AB. Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. PBS. 2021; 11(4): 249-257. doi:10.5455/PBS.20210610075010

Vancouver/ICMJE Style

Ermis B, Sagaltici E, Unal A, Alici D, Ozyurt AB. Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. PBS. (2021), [cited September 13, 2024]; 11(4): 249-257. doi:10.5455/PBS.20210610075010

Harvard Style

Ermis, B., Sagaltici, . E., Unal, . A., Alici, . D. & Ozyurt, . A. B. (2021) Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. PBS, 11 (4), 249-257. doi:10.5455/PBS.20210610075010

Turabian Style

Ermis, Berna, Eser Sagaltici, Ahmet Unal, Demet Alici, and Ayse Binnur Ozyurt. 2021. Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. Psychiatry and Behavioral Sciences, 11 (4), 249-257. doi:10.5455/PBS.20210610075010

Chicago Style

Ermis, Berna, Eser Sagaltici, Ahmet Unal, Demet Alici, and Ayse Binnur Ozyurt. "Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state." Psychiatry and Behavioral Sciences 11 (2021), 249-257. doi:10.5455/PBS.20210610075010

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Ermis, B., Sagaltici, . E., Unal, . A., Alici, . D. & Ozyurt, . A. B. (2021) Oxidative Metabolism and Oxidative DNA Damage in Bipolar Disorder: There are No Difference in Acute and Euthymic state. Psychiatry and Behavioral Sciences, 11 (4), 249-257. doi:10.5455/PBS.20210610075010

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